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Pharmacology

Antidepressant/NSAID Combo Linked to Brain Bleed Risk

Antidepressant/NSAID Combo Linked to Brain Bleed Risk

The combination of antidepressants and nonsteroidal anti-inflammatory drugs (NSAIDS) is linked to an early increased risk for intracranial hemorrhage, regardless of the type of NSAID or antidepressant, new research shows.
"The take-home message for clinicians is that special attention should be paid [to] antidepressant users when they start an NSAID prescription," coauthor Byung-Joo Park, MD, MPH, PhD, told Medscape Medical News. 

Too Many Patients With Migraine Receiving Opioids, Barbiturates

Washington, DC — Inappropriate prescribing of opioids and barbiturates for the treatment of migraine is common, a new study suggests. The study is the first to examine recent statistics on opioid and barbiturate-containing medication use in patients presenting to a headache center, said Mina T. Minen, MD, MPH, director of Headache Services and assistant professor in the Department of Neurology at New York University Langone Medical Center.
"We found it surprising that despite guidelines stating that these medications are not recommended as first-line treatments for primary headache disorders, [they] are still in use by a substantial number of patients," Dr Minen told 

100,000 avoidable deaths - Ian Bushfield

From: Ian Bushfield
Subject: 100,000 avoidable deaths
To: Rebecca Ward Consulting
Date: Fri, 29 Aug 2014 01:52:06 +0000

Dear friends,

Watch and share our 3 short new videos that show why we urgently need all clinical trials registered and results reported.Withholding results costs lives - The results of a 1980s clinical trial on heart drug Lorcainide were never published. Doctors didn’t know that more people died in the trial who were given Lorcainide than who were taking the placebo. It has been estimated that over 100,000 people died avoidably because they were prescribed drugs in the same class.

Top 20 Most Prescribed and Top-Selling US Drugs

Top 20 Most Prescribed, Top-Selling US Drugs

NB: Data from IMS Health. Figures reported are in $US and collected fromJuly 2013 - June 2014.

Left: The Top 20 US Drugs listed by Monthly Prescription (units) and Right: The Top 20 US drugs listed by total sales ($). Please take a look at the column totals and remember that this is only the top 20, only for 12 months and only for the USA ($82,293,753,189).
































Once again we have included some cheat sheets to view the indications and the drug groupings at a glance:

Antibiotics DON'T work...

Ah-Ah-choo!

Did you know that nearly 200 million doses of antibiotics are administered in hospitals to patients and among non-hospitalized patients, more than 130 million courses of antibiotics are prescribed by doctors each year? It is estimated that half of these latter prescriptions are unnecessary since they are being prescribed for colds, coughs and other viral infections*.


In cough and cold season please think CAREFULLY about your antibiotic use!
*NB: taken from the American College of Physicians website, Ref:

Drugs and Aged Care

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