Using statins may be associated with musculoskeletal conditions, arthropathies (joint diseases) and injuries, according to a report published by JAMA this week. It wasn’t that long ago that statins were under the microscope: Severe Rhabdomyolysis Associated with the Cerivastatin-Gemfibrozil Combination Therapy and we started to critically look at the long term benefits vs. the risks for the class.
While statins effectively lower cardiovascular illnesses and death, the full spectrum of statin musculoskeletal AEs is unknown. Statin-associated musculoskeletal AEs include a wide variety of clinical presentations, including rhabdomyolysis, muscle cramps and tendinous.
"Dr Ishak Mansi, of the VA North Texas Health Care System, Dallas, and colleagues utilised data to determine whether statins were associated with musculoskeletal conditions based on statin use. To our knowledge, this is the first study... to show that statin use is associated with an increased likelihood of diagnoses of musculoskeletal conditions, arthropathies and injuries. In our primary analysis, we did not find a statistically significant association between statin use and arthropathy; however, this association was statistically significant in all other analyses."
These findings are concerning because starting statin therapy at a young age for primary prevention of cardiovascular diseases has been widely advocated.